Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.57 |
| ▸ | HTR1B | P28222 | 5/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.56 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR1F | P30939 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385391 | 0.85 | SLC6A4 (0.52) | HTR1DHTR1BSLC6A4MTNR1AMTNR1B | |
| SCHEMBL8387179 | 0.85 | SLC6A4 (0.52) | HTR1DHTR1BSLC6A4MTNR1AMTNR1B | |
| SCHEMBL8713966 | 0.84 | HTR1D (0.55) | HTR1DHTR1BSLC6A4HTR1AHTR1F | |
| SCHEMBL8387312 | 0.83 | SLC6A4 (0.54) | HTR1DHTR1BSLC6A4HSD11B1HTR1A | |
| SCHEMBL8386447 | 0.83 | SLC6A4 (0.49) | HTR1DHTR1BSLC6A4NOS1MTNR1A | |
| SCHEMBL30908785 | 0.83 | SLC6A4 (0.49) | HTR1DHTR1BSLC6A4NOS1MTNR1A | |
| SCHEMBL6642008 | 0.82 | HTR1D (0.63) | HTR1DHTR1BSLC6A4NOS1MTNR1A | |
| SCHEMBL8381443 | 0.82 | CYP1A2 (0.63) | HTR1DHTR1BSLC6A4MTNR1AMTNR1B | |
| SCHEMBL8385393 | 0.82 | SLC6A4 (0.48) | HTR1DHTR1BSLC6A4MTNR1AMTNR1B | |
| SCHEMBL8711476 | 0.80 | SLC6A4 (0.47) | HTR1DHTR1BSLC6A4MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114049-B1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-03-19 | — | — | EP | disclosed |