Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7992298 | 0.99 | F2 (0.38) | F2PRSS1PRSS2PRSS3TSHR | |
| SCHEMBL6734250 | 0.79 | F2 (0.44) | F2PRSS1PRSS2PRSS3ADORA3 | |
| SCHEMBL6737271 | 0.77 | F2 (0.49) | F2PRSS1PRSS2PRSS3USP2 | |
| SCHEMBL7003096 | 0.73 | F2 (0.56) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL6995649 | 0.73 | F2 (0.56) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL6998939 | 0.73 | F2 (0.56) | F2PRSS1PRSS2PRSS3F10 | |
| Hydrochloric Acid SCHEMBL7978328 | 0.72 | F2 (0.56) | F2PRSS1PRSS2PRSS3F10 | |
| Hydrochloric Acid SCHEMBL7992439 | 0.72 | F2 (0.45) | F2PRSS1PRSS2PRSS3F10 | |
| Hydrochloric Acid SCHEMBL7989080 | 0.72 | F2 (0.56) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL6999390 | 0.72 | F2 (0.46) | F2PRSS1PRSS2PRSS3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |