Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6991411 | 1.00 | KDM4E (0.57) | KDM4ESMN1; SMN2POLBHRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL7094320 | 0.93 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBHRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL6992880 | 0.93 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBHRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL7094323 | 0.93 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBHRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL6997680 | 0.93 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBHRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL7087968 | 0.93 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBHRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL7087972 | 0.93 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBHRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL7087974 | 0.93 | KDM4E (0.53) | KDM4ESMN1; SMN2POLBHRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL6994186 | 0.88 | HRH3 (0.58) | HRH3KMT2AMEN1 | |
| Oxalic Acid SCHEMBL6991838 | 0.88 | HRH3 (0.58) | HRH3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853615-B1 | PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2003-12-10 | — | — | EP | disclosed |
| US-5981539-A | TREATMENT OF STROKE, ANOXIA, ISCHEMIA, MIGRAINE, PSYCHOSIS, EPILEPSY OR ANY OTHER CONVULSIVE DISORDER | NEUROSEARCH A/S (DK) | 1999-11-09 | — | — | US | disclosed |