Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.50 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | CCND1 | P24385 | 3/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.50 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092301 | 0.96 | KDR (0.50) | KDRCHEK1CDK2CCNE2CDK4 | |
| SCHEMBL7000955 | 0.91 | KDR (0.65) | KDRCHEK1CDK2CCNE2CDK4 | |
| SCHEMBL6999383 | 0.91 | KDR (0.54) | KDRCHEK1CDK2CCNE2CCNE1 | |
| SCHEMBL7095976 | 0.90 | CHEK1 (0.55) | KDRCHEK1CDK2CCNE2CDK4 | |
| SCHEMBL7093948 | 0.89 | CHEK1 (0.56) | KDRCHEK1CDK2CCNE2CDK4 | |
| SCHEMBL6996857 | 0.88 | KDR (0.61) | KDRCHEK1CDK2CCNE2CDK4 | |
| SCHEMBL7094049 | 0.83 | CHEK1 (0.60) | KDRCHEK1CDK2CDK1PDGFRB | |
| SCHEMBL7090565 | 0.81 | KDR (0.59) | KDRCHEK1CDK2CDK1PDGFRB | |
| SCHEMBL7704178 | 0.81 | CHEK1 (0.56) | KDRCHEK1CDK2KITFLT1 | |
| SCHEMBL6996897 | 0.81 | CHEK1 (0.65) | KDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |