Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.51 |
| ▸ | GAK | O14976 | 3/20 | 0.51 |
| ▸ | FBP1 | P09467 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
| ▸ | BUB1 | O43683 | 2/20 | 0.48 |
| ▸ | STK10 | O94804 | 2/20 | 0.48 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.48 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.48 |
| ▸ | CARS1 | P49589 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999413 | 0.89 | ABCG2 (0.54) | EGFRSYKABCG2DYRK1ADYRK1B | |
| SCHEMBL6997797 | 0.84 | EGFR (0.67) | EGFRERBB2 | |
| SCHEMBL6409884 | 0.83 | EGFR (0.62) | EGFRERBB2DAPK3ABL1RET | |
| SCHEMBL6991965 | 0.81 | EGFR (0.48) | EGFRSYK | |
| SCHEMBL7000944 | 0.81 | EGFR (0.53) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL6991896 | 0.80 | ABCG2 (0.56) | EGFRRAF1BRAFABCG2 | |
| SCHEMBL6996349 | 0.80 | EGFR (0.48) | EGFRRIPK2LMNARETSRC | |
| SCHEMBL6995062 | 0.79 | EGFR (0.51) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL8318849 | 0.79 | EGFR (0.55) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL8316734 | 0.79 | EGFR (0.55) | EGFRGAKFBP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |