Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 10/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.39 |
| ▸ | KDM3B | Q7LBC6 | 2/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998976 | 0.89 | CXCR2 (0.43) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6859654 | 0.84 | CXCR2 (0.46) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6864235 | 0.84 | CXCR2 (0.48) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6866466 | 0.83 | CXCR2 (0.46) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6866416 | 0.83 | CXCR2 (0.45) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6859473 | 0.81 | CXCR2 (0.43) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6866348 | 0.81 | CXCR2 (0.41) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6865043 | 0.80 | CXCR2 (0.45) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6864165 | 0.80 | CXCR2 (0.45) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A | |
| SCHEMBL6865517 | 0.80 | CXCR2 (0.44) | CXCR2GPR84SMN1; SMN2CXCR1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |