Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7167530 | 0.88 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL6994686 | 0.86 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL6999762 | 0.85 | MEN1 (0.65) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7492463 | 0.82 | MAPT (0.69) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7225773 | 0.79 | MAPT (0.50) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7163609 | 0.79 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7236400 | 0.79 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7498649 | 0.79 | MAPT (0.45) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7236396 | 0.79 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7160554 | 0.78 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003749-B1 | 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h/2,3/BENZODIAZEPINE DERIVATES, AS AMPA/KAINATERECEPTOR INHIBITORS | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2003-10-22 | — | — | EP | disclosed |
| US-6562810-B1 | Competitive AMPA/kainite antagonist properties making them useful in the treatment of diseases where inhibition of the AMPA/kainite receptors may a favorable effect | EGIS GYOGYSZERGYAR RT. (HU) | 2003-05-13 | — | — | US | disclosed |