Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 13/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001512 | 0.90 | PDE5A (0.42) | PDE5AKDM4EHDAC1HDAC6HDAC2 | |
| SCHEMBL6995296 | 0.90 | KDM4E (0.38) | PDE5AKDM4EHDAC1HDAC6HDAC2 | |
| SCHEMBL7004010 | 0.88 | PDE5A (0.40) | PDE5AKDM4EHDAC1HDAC6HDAC2 | |
| SCHEMBL7002254 | 0.88 | PDE5A (0.46) | PDE5AKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL7000319 | 0.84 | PDE5A (0.45) | PDE5A | |
| SCHEMBL7002358 | 0.84 | PDE5A (0.39) | PDE5AKDM4EHDAC1HDAC6HDAC2 | |
| SCHEMBL7001460 | 0.83 | PDE5A (0.47) | PDE5AKDM4EHDAC1KMT2AMEN1 | |
| SCHEMBL7003929 | 0.82 | PDE5A (0.40) | PDE5AKDM4EHDAC1HDAC6KMT2A | |
| SCHEMBL6999597 | 0.82 | PDE5A (0.40) | PDE5AKDM4EHDAC1HDAC6KMT2A | |
| SCHEMBL6777238 | 0.80 | PDE5A (0.42) | PDE5AKDM4EHDAC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |