Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD1 | P21728 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | DRD5 | P21918 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866221 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6995402 | 0.96 | KDM4E (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6860148 | 0.96 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6870547 | 0.92 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6864980 | 0.92 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6871061 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6868007 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6864581 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6860237 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6865004 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109785-B1 | INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MALIGNANT AND OTHER DISEASES CAUSED BY PATHOLOGICAL CELL PROLIFERATION | ZENTARIS AG (DE) | 2003-01-02 | — | — | EP | disclosed |