Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.69 |
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.69 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453743 | 0.86 | IGF1R (0.75) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL5254528 | 0.86 | IGF1R (0.75) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2204809 | 0.86 | IGF1R (0.81) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL7001957 | 0.82 | IGF1R (0.71) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL2200467 | 0.82 | IGF1R (0.67) | IGF1RMAP2K1EGFRERBB2 | |
| SCHEMBL4443456 | 0.82 | IGF1R (1.00) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL4454660 | 0.81 | MAP2K1 (1.00) | IGF1RMAP2K1MAPK3MAPK1MAP3K1 | |
| SCHEMBL4094649 | 0.81 | IGF1R (0.75) | IGF1RMAP2K1EGFR | |
| SCHEMBL5258048 | 0.81 | IGF1R (0.75) | IGF1RMAP2K1EGFR | |
| SCHEMBL2966953 | 0.81 | IGF1R (0.75) | IGF1RMAP2K1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | disclosed |
| US-6288082-B1 | COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | disclosed |
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |