Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 7/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700856 | 0.89 | BRAF (0.49) | AURKAAURKBCDK2CDK4CCNE1 | |
| SCHEMBL701005 | 0.87 | HDAC1 (0.61) | IKBKBCHUKIKBKGCDC7CDK19 | |
| SCHEMBL700078 | 0.84 | AURKA (0.53) | IKBKBCHUKIKBKGAURKAAURKB | |
| SCHEMBL699658 | 0.83 | HDAC1 (0.58) | CDK2CDK4CCNE1CDK1HDAC1 | |
| SCHEMBL703707 | 0.83 | CDK2 (0.47) | IKBKBCHUKIKBKGCDC7CDK19 | |
| SCHEMBL699357 | 0.82 | CDK2 (0.60) | CDK2CDK4CCNE1CDK1HDAC1 | |
| SCHEMBL700146 | 0.81 | CDK2 (0.49) | CDK2SYKCDK4CCNE1CDK1 | |
| SCHEMBL700145 | 0.81 | CDK2 (0.49) | AURKBCDK2CCNT1CDK9CDK4 | |
| SCHEMBL700984 | 0.80 | CDK2 (0.47) | CDK2FLT3CDK4CCNE1CDK1 | |
| SCHEMBL701179 | 0.79 | CDK2 (0.53) | CDK2CDK4CCNE1CDK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | claimed |
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-02-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC7 | IKBKB 252/4885CHUK 76/4885IKBKG 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.