Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.59 |
| ▸ | HTR1B | P28222 | 14/20 | 0.59 |
| ▸ | HTR1F | P30939 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999186 | 0.88 | HTR1D (0.58) | HTR1DHTR1BHTR1FHTR1AHTR6 | |
| SCHEMBL7000915 | 0.87 | HTR1D (0.62) | HTR1DHTR1BHTR1FHTR1AHTR6 | |
| SCHEMBL6999514 | 0.85 | HTR1D (0.59) | HTR1DHTR1BHTR1FHTR1AHTR6 | |
| SCHEMBL6999683 | 0.83 | HTR1D (0.63) | HTR1DHTR1BHTR1FHTR1AHTR6 | |
| SCHEMBL7484994 | 0.82 | HTR1D (0.67) | HTR1DHTR1BHTR1FHTR1AHTR6 | |
| SCHEMBL7487625 | 0.81 | HTR1D (0.72) | HTR1DHTR1BHTR1FHTR1AHTR6 | |
| SCHEMBL7481392 | 0.81 | HTR1D (0.74) | HTR1DHTR1BHTR1FHTR1AHTR6 | |
| SCHEMBL7535421 | 0.79 | HTR1D (0.78) | HTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL7477621 | 0.78 | HTR1D (0.76) | HTR1DHTR1BHTR1FHTR1AHTR6 | |
| SCHEMBL7481815 | 0.78 | HTR1D (0.76) | HTR1DHTR1BHTR1FHTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003738-B1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-19 | — | — | EP | claimed |
| EP-1003738-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | claimed |
| WO-1999007700-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-18 | — | — | WO | claimed |
| EP-1003738-B1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2003-11-19 | — | — | EP | disclosed |
| US-6391891-B1 | ANTISEROTONINE AGENT; ANXIOLYTIC AGENTS, ANTIDEPRESSANTS | SMITHKLINE BEECHAM PLC (GB) | 2002-05-21 | — | — | US | disclosed |
| EP-1003738-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007700-A1 | BICYCLIC COMPOUNDS AS LIGANDS FOR 5-HT1 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-18 | — | — | WO | disclosed |