Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 11/20 | 0.47 |
| ▸ | HPGDS | O60760 | 3/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700194 | 1.00 | PRCP (0.47) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL700213 | 0.98 | PRCP (0.48) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL700212 | 0.98 | PRCP (0.48) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL564194 | 0.97 | PRCP (0.48) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL203497 | 0.97 | PRCP (0.48) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL564193 | 0.97 | PRCP (0.48) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL564388 | 0.95 | PRCP (0.49) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL10039588 | 0.95 | PRCP (0.49) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL564390 | 0.95 | PRCP (0.49) | PRCPHPGDSHCRTR1HCRTR2NR1I2 | |
| SCHEMBL564389 | 0.95 | PRCP (0.49) | PRCPHPGDSHCRTR1HCRTR2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421855-A1 | DIARYL ETHERS | Tibotec Pharmaceuticals (IE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122162-A1 | DIARYL ETHERS | TIBOTEC PHARMACEUTICALS (IE) | 2010-10-28 | — | — | WO | disclosed |