Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999933 | 0.89 | MEN1 (0.37) | MEN1POLBKMT2AHCRTR2CCR3 | |
| SCHEMBL6761301 | 0.86 | HCRTR2 (0.40) | HCRTR2CCR3HCRTR1 | |
| SCHEMBL6996220 | 0.86 | CCR1 (0.43) | HTR1ADRD4HTR2ASLC6A4HTR7 | |
| SCHEMBL6761297 | 0.86 | HCRTR2 (0.40) | HCRTR2CCR3HCRTR1 | |
| SCHEMBL6997076 | 0.85 | GAA (0.42) | MEN1POLBKMT2AHCRTR2CCR3 | |
| SCHEMBL6996406 | 0.85 | CCR1 (0.42) | MEN1POLBKMT2ACCR3 | |
| SCHEMBL6999918 | 0.82 | CCR1 (0.40) | — | |
| SCHEMBL6996562 | 0.80 | POLB (0.54) | MEN1POLBKMT2AL3MBTL1 | |
| SCHEMBL6998823 | 0.77 | CCR1 (0.46) | MEN1POLBKMT2ACCR3 | |
| SCHEMBL7000468 | 0.77 | CCR1 (0.47) | MEN1POLBKMT2ACCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326867-A2 | BRIDGED PIPERAZINE DERIVATIVES | Pfizer Products Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032901-A2 | BRIDGED PIPERAZINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2002-04-25 | — | — | WO | disclosed |