Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999224 | 0.93 | PDE5A (0.73) | PDE5A | |
| SCHEMBL6999218 | 0.91 | PDE5A (0.66) | PDE5A | |
| SCHEMBL6998956 | 0.88 | PDE5A (0.66) | PDE5A | |
| SCHEMBL7003048 | 0.88 | PDE5A (0.66) | PDE5A | |
| SCHEMBL7002031 | 0.87 | PDE5A (0.66) | PDE5A | |
| SCHEMBL6999215 | 0.86 | PDE5A (0.64) | PDE5A | |
| SCHEMBL6997711 | 0.86 | PDE5A (0.64) | PDE5A | |
| SCHEMBL7000798 | 0.86 | PDE5A (0.74) | PDE5A | |
| SCHEMBL7001212 | 0.85 | PDE5A (0.67) | PDE5A | |
| SCHEMBL6999347 | 0.85 | PDE5A (0.71) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |