Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817380 | 0.85 | MEN1 (0.48) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL27879537 | 0.81 | KMT2A (0.50) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL7003948 | 0.79 | MEN1 (0.44) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL3835799 | 0.79 | MEN1 (0.55) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL4119009 | 0.76 | MEN1 (0.44) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL12469312 | 0.76 | SLC6A2 (0.46) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL27136016 | 0.76 | MEN1 (0.44) | KMT2AMEN1ALDH1A1KDM4ENPC1 | |
| SCHEMBL18124244 | 0.73 | MEN1 (0.42) | KMT2AMEN1OPRM1 | |
| SCHEMBL30146872 | 0.72 | HDAC3 (0.53) | KMT2AMEN1L3MBTL1HDAC3HDAC1 | |
| SCHEMBL2588241 | 0.72 | CHRM2 (0.42) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286967-A1 | CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001087838-A1 | CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-22 | — | — | WO | disclosed |