Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 7/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447066 | 0.87 | EGFR (0.76) | EGFRERBB2MAP2K1IGF1RMAPK3 | |
| SCHEMBL7003639 | 0.86 | MAP2K1 (0.64) | EGFRERBB2MAP2K1IGF1RMAPK3 | |
| SCHEMBL6998163 | 0.83 | MAP2K1 (0.79) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL6995035 | 0.81 | MAP2K1 (0.73) | EGFRERBB2MAP2K1IGF1RMAPK3 | |
| SCHEMBL7001584 | 0.81 | MAP2K1 (0.73) | EGFRERBB2MAP2K1IGF1RMAPK3 | |
| SCHEMBL6997884 | 0.81 | MAP2K1 (0.63) | EGFRERBB2MAP2K1IGF1RMAPK3 | |
| SCHEMBL6999091 | 0.81 | MAP2K1 (0.61) | EGFRERBB2MAP2K1IGF1RMAPK3 | |
| SCHEMBL6383146 | 0.81 | EGFR (0.75) | EGFRERBB2MAP2K1IGF1RMAPK3 | |
| SCHEMBL7003056 | 0.81 | MAP2K1 (0.58) | EGFRERBB2MAP2K1IGF1RMAPK3 | |
| SCHEMBL6382853 | 0.81 | EGFR (0.58) | EGFRERBB2MAP2K1MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |