Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.66 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 13/20 | 0.57 |
| ▸ | KDM1B | Q8NB78 | 3/20 | 0.57 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 7/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8144697 | 1.00 | DPP4 (0.66) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| SCHEMBL30052677 | 1.00 | DPP4 (0.66) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| SCHEMBL15542134 | 1.00 | DPP4 (0.66) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| SCHEMBL8144699 | 1.00 | DPP4 (0.66) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| SCHEMBL31508220 | 1.00 | DPP4 (0.66) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| SCHEMBL29546108 | 1.00 | DPP4 (0.66) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| SCHEMBL7002501 | 1.00 | DPP4 (0.66) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| Hydrochloric Acid SCHEMBL15541881 | 0.98 | DPP4 (0.63) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| Hydrochloric Acid SCHEMBL15541879 | 0.98 | DPP4 (0.63) | DPP4HTR2CHTR2AHTR2BKDM1A | |
| Trifluoroacetic Acid SCHEMBL15541005 | 0.83 | DPP4 (0.49) | DPP4HTR2CHTR2AHTR2BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |