Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.41 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002531 | 1.00 | FFAR1 (0.56) | FFAR1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29302328 | 0.88 | FFAR1 (0.49) | FFAR1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7868650 | 0.82 | FFAR1 (0.65) | FFAR1ALDH1A1LMNAIDO1HDAC4 | |
| SCHEMBL10288305 | 0.82 | FFAR1 (0.65) | FFAR1ALDH1A1LMNAIDO1HDAC4 | |
| SCHEMBL3042239 | 0.82 | FFAR1 (0.65) | FFAR1ALDH1A1LMNAIDO1HDAC4 | |
| SCHEMBL23116570 | 0.82 | FFAR1 (0.65) | FFAR1ALDH1A1LMNAIDO1HDAC4 | |
| SCHEMBL21501054 | 0.82 | FFAR1 (0.65) | FFAR1ALDH1A1LMNAIDO1HDAC4 | |
| SCHEMBL31076307 | 0.80 | FFAR1 (0.49) | FFAR1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL32677647 | 0.80 | FFAR1 (0.49) | FFAR1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL19628622 | 0.80 | FFAR1 (0.81) | FFAR1ALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |