Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997083 | 0.87 | HTR2C (0.47) | HTR2CSLC6A2SLC6A4HTR6FABP4 | |
| SCHEMBL2071536 | 0.85 | SLC6A2 (0.63) | HTR2CSLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL2074697 | 0.81 | SLC6A2 (0.44) | SLC6A2SLC6A4NR3C2ATMSLC6A3 | |
| SCHEMBL2074699 | 0.81 | SLC6A2 (0.44) | SLC6A2SLC6A4NR3C2ATMSLC6A3 | |
| SCHEMBL2074273 | 0.76 | SLC6A4 (0.53) | HTR2CSLC6A2SLC6A4NR3C2SLC6A3 | |
| SCHEMBL2073887 | 0.75 | SLC6A4 (0.67) | SLC6A2SLC6A4 | |
| SCHEMBL3223128 | 0.74 | FGFR1 (0.35) | SLC6A2SLC6A4OPRM1OPRK1SLC6A3 | |
| SCHEMBL3223123 | 0.74 | FGFR1 (0.35) | SLC6A2SLC6A4OPRM1OPRK1SLC6A3 | |
| SCHEMBL3218067 | 0.72 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL3225487 | 0.72 | SLC6A2 (0.43) | SLC6A2SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140943-B1 | SUBSTITUTED PYRROLOINDOLES | LILLY CO ELI (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6448284-B1 | PYRROLO(1,2-A)INDOLES; INHIBITING NONPANCREATIC SECRETORY PHOSPHOLIPASE A2 MEDIATED RELEASE OF FATTY ACIDS; SEPTIC SHOCK | ELI LILLY AND COMPANY | 2002-09-10 | — | — | US | disclosed |
| EP-1140943-A2 | SUBSTITUTED PYRROLOINDOLES | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037472-A2 | SUBSTITUTED PIRROLOINDOLES | ELI LILLY AND COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |