Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | UBE2I | P63279 | 2/20 | 0.55 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.55 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669596 | 1.00 | JAK2 (0.60) | JAK2IKBKBJAK3MAPTKMT2A | |
| SCHEMBL7002439 | 0.81 | JAK2 (0.59) | JAK2IKBKBJAK3MAPTKMT2A | |
| SCHEMBL7673880 | 0.81 | JAK2 (0.59) | JAK2IKBKBJAK3MAPTKMT2A | |
| SCHEMBL17318556 | 0.78 | JAK2 (0.67) | JAK2IKBKBJAK3 | |
| SCHEMBL1385889 | 0.76 | JAK2 (1.00) | JAK2IKBKBJAK3KMT2ATDP1 | |
| SCHEMBL6997954 | 0.74 | JAK2 (0.62) | JAK2IKBKBJAK3MAPTKMT2A | |
| SCHEMBL6614249 | 0.74 | JAK2 (0.78) | JAK2IKBKBJAK3 | |
| SCHEMBL5898695 | 0.74 | JAK2 (0.78) | JAK2IKBKBJAK3 | |
| SCHEMBL5821205 | 0.73 | JAK2 (0.72) | JAK2IKBKBJAK3MAPTKMT2A | |
| SCHEMBL5821206 | 0.73 | JAK2 (0.72) | JAK2IKBKBJAK3MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |