Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 19/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6697452 | 0.93 | F10 (0.87) | F10KCNH2KLK1 | |
| SCHEMBL6692670 | 0.91 | F10 (0.87) | F10KCNH2 | |
| SCHEMBL6697421 | 0.91 | F10 (0.87) | F10KCNH2 | |
| SCHEMBL6698359 | 0.91 | F10 (0.85) | F10KCNH2KLK1 | |
| SCHEMBL6700862 | 0.90 | F10 (0.82) | F10KCNH2KLK1 | |
| SCHEMBL6697112 | 0.86 | F10 (0.79) | F10KCNH2KLK1 | |
| SCHEMBL6698435 | 0.86 | F10 (0.75) | F10KCNH2KLK1 | |
| SCHEMBL6698438 | 0.86 | F10 (0.75) | F10KCNH2KLK1 | |
| SCHEMBL7006197 | 0.86 | F10 (0.74) | F10KCNH2 | |
| SCHEMBL6703106 | 0.84 | F10 (0.86) | F10KCNH2KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322643-A1 | PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR XA | Millennium Pharmaceuticals, Inc. (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026734-A1 | PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2002-04-04 | — | — | WO | disclosed |