Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200467 | 0.86 | IGF1R (0.67) | EGFRERBB2IGF1RMAP2K1 | |
| SCHEMBL6998144 | 0.83 | IGF1R (0.66) | EGFRIGF1RMAP2K1IKBKBLYN | |
| SCHEMBL7000398 | 0.76 | IGF1R (0.75) | EGFRERBB2IGF1RMAP2K1 | |
| SCHEMBL5255712 | 0.76 | IGF1R (0.68) | EGFRERBB2IGF1RMAP2K1 | |
| SCHEMBL6381500 | 0.76 | EGFR (0.59) | EGFRERBB2 | |
| SCHEMBL7002118 | 0.76 | IGF1R (0.74) | EGFRERBB2IGF1RMAP2K1 | |
| SCHEMBL7001957 | 0.76 | IGF1R (0.71) | EGFRERBB2IGF1RMAP2K1 | |
| SCHEMBL7001176 | 0.75 | MAP2K1 (0.77) | EGFRIGF1RMAP2K1IKBKBLYN | |
| SCHEMBL6381274 | 0.75 | EGFR (0.56) | EGFRERBB2PRKCQ | |
| SCHEMBL4894138 | 0.75 | IGF1R (0.68) | EGFRIGF1RMAP2K1IKBKBLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |