Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001004 | 0.91 | PARP1 (0.71) | PARP1HSD17B10ALOX15TP53POLB | |
| SCHEMBL6992162 | 0.85 | PARP1 (0.55) | PARP1HSD17B10TP53POLBSMN1; SMN2 | |
| SCHEMBL532477 | 0.85 | PARP1 (1.00) | PARP1HSD17B10ALOX15TP53POLB | |
| SCHEMBL6310170 | 0.83 | PARP1 (0.95) | PARP1HSD17B10ALOX15TP53POLB | |
| SCHEMBL10267424 | 0.80 | PARP1 (0.88) | PARP1TP53POLBSMN1; SMN2 | |
| SCHEMBL6302991 | 0.79 | PARP1 (0.90) | PARP1TP53POLBSMN1; SMN2USP2 | |
| SCHEMBL6305288 | 0.79 | PARP1 (0.88) | PARP1HSD17B10TP53POLBSMN1; SMN2 | |
| SCHEMBL29498308 | 0.77 | MAOB (0.49) | PARP1HSD17B10ALOX15SMN1; SMN2MAPK1 | |
| SCHEMBL6991112 | 0.77 | PARP1 (0.53) | PARP1HSD17B10TP53POLBSMN1; SMN2 | |
| SCHEMBL10262368 | 0.76 | PARP1 (0.82) | PARP1HSD17B10ALOX15GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015437-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |