Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | PDE6C | P51160 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200638 | 0.93 | PDE5A (0.68) | PDE5AKMT2APDE6CKDM4ERXFP1 | |
| SCHEMBL6446727 | 0.92 | PDE5A (0.54) | PDE5AKMT2APDE6CKDM4ERXFP1 | |
| SCHEMBL6446606 | 0.92 | PDE5A (0.54) | PDE5AKMT2APDE6CKDM4ERXFP1 | |
| SCHEMBL6444896 | 0.92 | PDE5A (0.62) | PDE5AKMT2APDE6CKDM4ERXFP1 | |
| SCHEMBL7005723 | 0.90 | PDE5A (0.56) | PDE5AKMT2APDE6CKDM4ERXFP1 | |
| SCHEMBL6444195 | 0.87 | PDE5A (0.56) | PDE5AKMT2APDE6CKDM4EALDH1A1 | |
| SCHEMBL6200684 | 0.87 | PDE5A (0.60) | PDE5AKMT2APDE6C | |
| SCHEMBL6443433 | 0.86 | PDE5A (0.56) | PDE5AKMT2APDE6CKDM4ERXFP1 | |
| SCHEMBL6446584 | 0.86 | PDE5A (0.55) | PDE5AKMT2APDE6CKDM4EALDH1A1 | |
| SCHEMBL6446331 | 0.85 | PDE5A (0.55) | PDE5AKMT2APDE6CKDM4ERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |