Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL94206 | 1.00 | MAPK1 (0.43) | MAPK1KDM4EALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL5250892 | 1.00 | MAPK1 (0.43) | MAPK1KDM4EALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL132894 | 0.94 | MAPK1 (0.42) | MAPK1L3MBTL3L3MBTL1TP53BP1SRD5A2 | |
| SCHEMBL863778 | 0.91 | MAPK1 (0.43) | MAPK1KDM4EALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL11008209 | 0.87 | MAPK1 (0.43) | MAPK1KDM4EALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL11003669 | 0.85 | MAPK1 (0.42) | MAPK1L3MBTL3L3MBTL1OPRM1OPRL1 | |
| SCHEMBL863645 | 0.85 | MAPK1 (0.42) | MAPK1L3MBTL3L3MBTL1TP53BP1OPRM1 | |
| SCHEMBL8149056 | 0.85 | MAPK1 (0.33) | MAPK1KDM4EALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL1822607 | 0.84 | MAPK1 (0.45) | MAPK1ALDH1A1L3MBTL3L3MBTL1CTDSP1 | |
| SCHEMBL30761740 | 0.83 | MAPK1 (0.41) | MAPK1ALDH1A1L3MBTL3L3MBTL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007063418-A2 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2007-06-07 | — | — | WO | disclosed |
| US-6562809-B1 | Contraction of coronary arteries may be mediated by its stimulation of the 5-HT1B (formerly 5-HT1D beta); compounds selective for a 5-HT1D receptor | NPS ALLELIX CORP. (CA) | 2003-05-13 | — | — | US | disclosed |
| EP-1114049-B1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-03-19 | — | — | EP | disclosed |
| EP-1114049-A1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS Allelix Corp. (CA) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017198-A1 | 3-BICYCLOINDOLE COMPOUNDS AS 5-HT1D LIGANDS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-03-30 | — | — | WO | disclosed |