Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 12/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 11/20 | 0.40 |
| ▸ | TUBB | P07437 | 11/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 11/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 11/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 11/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 11/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 11/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 11/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 11/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 11/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 11/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 11/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 11/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 11/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003766 | 1.00 | CCNT1 (0.42) | CCNT1CDK7CDK9CCNHTUBB1 | |
| SCHEMBL6998414 | 0.81 | CDK7 (0.39) | CCNT1CDK7CDK9CCNHTUBB1 | |
| SCHEMBL6998419 | 0.81 | CDK7 (0.39) | CCNT1CDK7CDK9CCNHTUBB1 | |
| SCHEMBL6998422 | 0.81 | CDK7 (0.39) | CCNT1CDK7CDK9CCNHTUBB1 | |
| SCHEMBL7003171 | 0.80 | CDK7 (0.45) | CCNT1CDK7CDK9CCNH | |
| SCHEMBL7003473 | 0.80 | CDK7 (0.45) | CCNT1CDK7CDK9CCNH | |
| SCHEMBL7003168 | 0.80 | CDK7 (0.45) | CCNT1CDK7CDK9CCNH | |
| SCHEMBL7004689 | 0.80 | CDK7 (0.38) | CCNT1CDK7CDK9CCNHTUBB1 | |
| SCHEMBL7004692 | 0.80 | CDK7 (0.38) | CCNT1CDK7CDK9CCNHTUBB1 | |
| SCHEMBL7002136 | 0.79 | CCNT1 (0.36) | CCNT1CDK7CDK9CCNHTUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081149-B1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6372749-B1 | PHARMACOLOGICAL EFFECTS SUCH AS ANALGESIC ACTION, INHIBITORY EFFECT ON NITROGEN MONOXIDE SYNTHETASE AND THE LIKE AND ARE USEFUL AS ANALGESICS. | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1081149-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-03-07 | — | — | EP | disclosed |