Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | STK4 | Q13043 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000306 | 0.91 | SRC (0.42) | SRCEGFRERBB2PRKCQKDM4E | |
| SCHEMBL7000865 | 0.90 | SRC (0.43) | SRCEGFRERBB2PRKCQKDM4E | |
| SCHEMBL6999119 | 0.90 | SRC (0.43) | SRCEGFRERBB2PRKCQKDM4E | |
| SCHEMBL7003243 | 0.89 | MAPT (0.48) | SRCEGFRERBB2KDM4EALDH1A1 | |
| SCHEMBL7000645 | 0.89 | EGFR (0.51) | SRCEGFRERBB2PRKCQKDM4E | |
| SCHEMBL7001574 | 0.88 | IGF1R (0.40) | SRCEGFRERBB2PRKCQKDM4E | |
| SCHEMBL6998133 | 0.86 | PRKCQ (0.49) | SRCEGFRERBB2PRKCQKDM4E | |
| SCHEMBL6999325 | 0.86 | SRC (0.54) | SRCPRKCQ | |
| SCHEMBL6997390 | 0.86 | SRC (0.41) | SRCEGFRERBB2PRKCQKDM4E | |
| SCHEMBL6999233 | 0.84 | SRC (0.47) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |