SCHEMBL7004268

SCHEMBL7004268

N[C@@H]1CC1c1ccc(Cl)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 15/20 0.48
KCNH2 Q12809 5/20 0.48
KDM1B Q8NB78 3/20 0.48
MAOB P27338 6/20 0.48
RCOR1 Q9UKL0 3/20 0.48
SLC6A2 P23975 2/20 0.47
SLC6A3 Q01959 2/20 0.47
TAAR1 Q96RJ0 1/20 0.47
MAOA P21397 4/20 0.46
CYP2C19 P33261 3/20 0.46
CYP2B6 P20813 2/20 0.46
CYP1A2 P05177 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C9 P11712 2/20 0.46
LMNA P02545 1/20 0.46
CYP3A4 P08684 1/20 0.46
HTR1A P08908 1/20 0.46
ADRA2A P08913 1/20 0.46
CYP2A6 P11509 1/20 0.46
HTR2C P28335 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7095292 1.00 KDM1A (0.48) KDM1AKCNH2KDM1BMAOBRCOR1
SCHEMBL8146309 1.00 KDM1A (0.48) KDM1AKCNH2KDM1BMAOBRCOR1
SCHEMBL7004269 1.00 KDM1A (0.48) KDM1AKCNH2KDM1BMAOBRCOR1
SCHEMBL4508197 0.82 SLC6A4 (0.41) KDM1AKDM1BSLC6A2SLC6A3
SCHEMBL7089683 0.82 CYP3A4 (0.45) KDM1AKCNH2KDM1BMAOBRCOR1
SCHEMBL7001619 0.82 CYP3A4 (0.45) KDM1AKCNH2KDM1BMAOBRCOR1
SCHEMBL8134479 0.82 CYP3A4 (0.45) KDM1AKCNH2KDM1BMAOBRCOR1
SCHEMBL7001620 0.82 CYP3A4 (0.45) KDM1AKCNH2KDM1BMAOBRCOR1
SCHEMBL7003893 0.82 KCNH2 (0.45) KDM1AKCNH2KDM1BMAOBRCOR1
SCHEMBL7003889 0.82 KCNH2 (0.45) KDM1AKCNH2KDM1BMAOBRCOR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0996621-B1 TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS ASTRAZENECA AB (SE) 2003-10-01 EP disclosed
US-6251910-B1 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists ASTRAZENECA UK LIMITED (GB) 2001-06-26 US disclosed