Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006609 | 0.94 | DPP4 (0.50) | DPP4L3MBTL1ALDH1A1POLBSIRT5 | |
| SCHEMBL7004547 | 0.90 | DPP4 (0.59) | DPP4L3MBTL1ALDH1A1GPR18TSHR | |
| SCHEMBL7006612 | 0.85 | DPP4 (0.65) | DPP4L3MBTL1ALDH1A1GPR18TSHR | |
| SCHEMBL5641836 | 0.78 | MEN1 (0.52) | DPP4L3MBTL1ALDH1A1POLBSIRT5 | |
| SCHEMBL5641843 | 0.76 | DPP4 (0.71) | DPP4L3MBTL1ALDH1A1POLBSIRT5 | |
| SCHEMBL5641868 | 0.75 | DPP4 (0.75) | DPP4L3MBTL1ALDH1A1TSHRNPSR1 | |
| SCHEMBL5642153 | 0.73 | DPP4 (0.77) | DPP4L3MBTL1ALDH1A1POLBSIRT5 | |
| SCHEMBL5642757 | 0.71 | DPP4 (0.69) | DPP4L3MBTL1ALDH1A1POLBSIRT5 | |
| SCHEMBL5644237 | 0.71 | DPP4 (0.49) | DPP4L3MBTL1ALDH1A1POLBSIRT5 | |
| SCHEMBL5642868 | 0.70 | DPP4 (0.88) | DPP4L3MBTL1ALDH1A1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301187-A2 | HETEROCYCLIC COMPOUNDS, WHICH ARE INHIBITORS OF THE ENZYME DPP-IV | NOVO NORDISK A/S (DK) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002002560-A2 | PURINE-2,6-DIONES WHICH ARE INHIBITORS OF THE ENZYME DIPEPTIDYL PEPTIDASE IV (DPP-IV) | NOVO NORDISK A/S (DK) | 2002-01-10 | — | — | WO | disclosed |