Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.62 |
| ▸ | LCK | P06239 | 7/20 | 0.62 |
| ▸ | TEK | Q02763 | 7/20 | 0.62 |
| ▸ | SRC | P12931 | 10/20 | 0.59 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | ABL1 | P00519 | 6/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007913 | 0.92 | KDR (0.65) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7012365 | 0.91 | KDR (0.64) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7013873 | 0.90 | KDR (0.63) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7097902 | 0.90 | KDR (0.63) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7006212 | 0.90 | KDR (0.74) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7007563 | 0.89 | KDR (0.62) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7007578 | 0.87 | KDR (0.59) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7006502 | 0.87 | LCK (0.81) | KDRLCKTEKSRCEGFR | |
| SCHEMBL7009870 | 0.85 | KDR (0.61) | KDRLCKTEKSRCEGFR | |
| SCHEMBL8145098 | 0.85 | KDR (0.61) | KDRLCKTEKSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |