Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 18/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | PDE2A | O00408 | 2/20 | 0.54 |
| ▸ | PDE9A | O76083 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.54 |
| ▸ | PDE6C | P51160 | 2/20 | 0.54 |
| ▸ | PDE1A | P54750 | 2/20 | 0.54 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.53 |
| ▸ | PDE6D | O43924 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004922 | 0.88 | PDE5A (0.61) | KDM4EPDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL7006271 | 0.88 | PDE5A (0.57) | PDE5AHDAC1HDAC2HDAC6HDAC3 | |
| SCHEMBL7004870 | 0.87 | PDE5A (0.74) | KDM4EPDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL7240467 | 0.87 | PDE5A (0.60) | KDM4EPDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL7096466 | 0.86 | PDE5A (0.67) | KDM4EPDE5APDE2APDE9APDE4A | |
| SCHEMBL7002311 | 0.85 | KDM4E (0.62) | KDM4EPDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL7001089 | 0.84 | KDM4E (0.61) | KDM4EPDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL7005470 | 0.83 | KDM4E (0.60) | KDM4EPDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL7095471 | 0.82 | PDE5A (0.61) | KDM4EPDE5AHDAC1HDAC2HDAC6 | |
| SCHEMBL7001170 | 0.82 | KDM4E (0.58) | KDM4EPDE5AHDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716298-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2014-05-06 | — | — | US | claimed |
| EP-2556820-A2 | COMPOSITION CONTAINING PDE5 INHIBITOR FOR RELIEVING SKIN WRINKLES | SK Chemicals, Co., Ltd. (KR) | 2013-02-13 | — | — | EP | claimed |
| US-20130030174-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2013-01-31 | — | — | US | claimed |
| EP-1129093-B1 | PYRAZOLOPYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF IMPOTENCE | DONG A PHARM CO LTD (KR) | 2003-07-23 | — | — | EP | claimed |
| US-6583147-B1 | 5-(2-ethoxy-5-(isopropylamidosulfonyl)phenyl)-1-methyl-3-propy l- 1,6-dihydro-7H-pyrazolo(4,3-d)pyrimidin-7-one; | DONG A PHARM CO., LTD. (KR) | 2003-06-24 | — | — | US | claimed |
| US-9155691-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2015-10-13 | — | — | US | disclosed |
| US-20140179701-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2014-06-26 | — | — | US | disclosed |
| US-8716298-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2014-05-06 | — | — | US | disclosed |
| EP-2556820-A2 | COMPOSITION CONTAINING PDE5 INHIBITOR FOR RELIEVING SKIN WRINKLES | SK Chemicals, Co., Ltd. (KR) | 2013-02-13 | — | — | EP | disclosed |
| US-20130030174-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2013-01-31 | — | — | US | disclosed |
| US-6583147-B1 | 5-(2-ethoxy-5-(isopropylamidosulfonyl)phenyl)-1-methyl-3-propy l- 1,6-dihydro-7H-pyrazolo(4,3-d)pyrimidin-7-one; | DONG A PHARM CO., LTD. (KR) | 2003-06-24 | — | — | US | disclosed |