Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.64 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867491 | 1.00 | GRIK1 (0.64) | GRIK1MMP1MMP2MMP3MMP9 | |
| SCHEMBL1856639 | 0.93 | GRIK1 (0.72) | GRIK1MMP1MMP2MMP3MMP9 | |
| SCHEMBL1860416 | 0.89 | GRIK1 (0.68) | GRIK1MMP1MMP2MMP3MMP9 | |
| SCHEMBL3272788 | 0.89 | CYP1A2 (0.53) | GRIK1CYP1A2TDP1CPA3CPA1 | |
| SCHEMBL18241164 | 0.87 | GRIK1 (0.66) | GRIK1MMP1MMP2MMP3MMP9 | |
| SCHEMBL18241165 | 0.87 | GRIK1 (0.66) | GRIK1MMP1MMP2MMP3MMP9 | |
| SCHEMBL1131425 | 0.84 | GRIK1 (0.62) | GRIK1MMP1MMP2MMP3MMP9 | |
| SCHEMBL8868075 | 0.84 | GRIK1 (0.62) | GRIK1MMP1MMP2MMP3MMP9 | |
| SCHEMBL19438906 | 0.84 | GRIK1 (0.67) | GRIK1MMP1MMP2MMP3MMP9 | |
| SCHEMBL1861360 | 0.84 | GRIK1 (0.62) | GRIK1MMP1MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347978-A1 | NOVEL SUBSTITUTED IMIDAZOTRIAZINONES AS PDE II-INHIBITORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002050078-A1 | NOVEL SUBSTITUTED IMIDAZOTRIAZINONES AS PDE II-INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-06-27 | — | — | WO | disclosed |