Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD known ✓ | Q03181 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 20/20 | 0.56 |
| ▸ | PPARA | Q07869 | 18/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7002752 | 1.00 | PPARG (0.56) | PPARGPPARAPPARD | |
| SCHEMBL7005331 | 0.91 | PPARG (0.48) | PPARGPPARAPPARD | |
| SCHEMBL6555767 | 0.90 | PPARG (0.68) | PPARGPPARAPPARD | |
| SCHEMBL7004808 | 0.89 | PPARG (0.67) | PPARGPPARAPPARD | |
| SCHEMBL7006234 | 0.89 | PPARG (0.67) | PPARGPPARAPPARD | |
| Lithium SCHEMBL7004819 | 0.89 | PPARG (0.67) | PPARGPPARAPPARD | |
| Arginine SCHEMBL7004117 | 0.89 | PPARG (0.51) | PPARGPPARAPPARD | |
| Arginine SCHEMBL7006540 | 0.89 | PPARG (0.51) | PPARGPPARAPPARD | |
| Tromethamine SCHEMBL7004271 | 0.85 | PPARG (0.60) | PPARGPPARAPPARD | |
| Lysine SCHEMBL7007772 | 0.85 | PPARG (0.50) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363913-A2 | SALTS OF PYRIMIDINE DERIVATIVES FOR USE AGAINST CORONARY HEART DISEASE AND ATHEROSCLEROSE | Dr. Reddy's Laboratories Ltd. (IN) | 2003-11-26 | — | — | EP | claimed |
| WO-2002062798-A2 | SALTS OF PYRIMIDINE DERIVATIVES FOR USE AGAINST CORONARY HEART DISEASE AND ATHEROSCLEROSE | DR. REDDY'S LABORATORIES LTD. (IN) | 2002-08-15 | — | — | WO | claimed |
| EP-1363913-A2 | SALTS OF PYRIMIDINE DERIVATIVES FOR USE AGAINST CORONARY HEART DISEASE AND ATHEROSCLEROSE | Dr. Reddy's Laboratories Ltd. (IN) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002062798-A2 | SALTS OF PYRIMIDINE DERIVATIVES FOR USE AGAINST CORONARY HEART DISEASE AND ATHEROSCLEROSE | DR. REDDY'S LABORATORIES LTD. (IN) | 2002-08-15 | — | — | WO | disclosed |