⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985544 | 0.67 | — | — | |
| SCHEMBL2446 | 0.65 | — | — | |
| SCHEMBL148986 | 0.65 | — | — | |
| SCHEMBL16167388 | 0.65 | — | — | |
| SCHEMBL513803 | 0.61 | — | — | |
| SCHEMBL514443 | 0.61 | — | — | |
| SCHEMBL2961643 | 0.61 | — | — | |
| SCHEMBL97426 | 0.61 | — | — | |
| SCHEMBL513802 | 0.61 | — | — | |
| SCHEMBL2961645 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030195196-A1 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2003-10-16 | — | — | US | disclosed |
| EP-1109811-B1 | PYRROLOBENZODIAZEPINES | SPIROGEN LTD (GB) | 2003-08-06 | — | — | EP | disclosed |
| US-6562806-B1 | A prodrug may be converted into an antitumour agent under the influence of an enzyme that is linked to a monoclonal antibody so that it can bind to a tumour associated antigen | SPIROGEN LIMITED (GB) | 2003-05-13 | — | — | US | disclosed |
| EP-1109811-A2 | PYRROLOBENZODIAZEPINES | Spirogen Limited (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012507-A2 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |
| EP-0099329-B1 | DITHIO COMPOUNDS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE | Zyma SA (CH) | 1990-10-31 | — | — | EP | disclosed |
| US-4946861-A | TREATMENT OF LIVER DISORDERS | ZYMA SA (CH) | 1990-08-07 | — | — | US | disclosed |
| US-4818765-A | TREATING LIVER, RESPIRATORY TRACT, VASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1989-04-04 | — | — | US | disclosed |
| EP-0099329-A1 | Dithio compounds, pharmaceutical preparations containing them and their use | Zyma SA (CH) | 1984-01-25 | — | — | EP | disclosed |