Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.51 |
| ▸ | ITK | Q08881 | 9/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | TXK | P42681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005166 | 0.87 | NTRK1 (0.64) | NTRK1ITKCDK2 | |
| SCHEMBL7002877 | 0.86 | NTRK1 (0.49) | NTRK1ITKJAK3BTKCDK2 | |
| SCHEMBL7008526 | 0.84 | NTRK1 (0.50) | NTRK1ITKJAK3BTKCDK2 | |
| SCHEMBL5658099 | 0.78 | NTRK1 (0.77) | NTRK1ITKCDK2 | |
| SCHEMBL7002646 | 0.77 | NTRK1 (0.76) | NTRK1ITKJAK3BTKCDK2 | |
| SCHEMBL7005357 | 0.77 | NTRK1 (0.66) | NTRK1ITKJAK3BTKCDK2 | |
| SCHEMBL5658075 | 0.69 | NTRK1 (0.75) | NTRK1ITKJAK3BTKTXK | |
| SCHEMBL20161915 | 0.68 | JAK3 (0.80) | NTRK1ITKJAK3BTKTXK | |
| SCHEMBL5657008 | 0.65 | NTRK1 (1.00) | NTRK1ITKCDK2 | |
| SCHEMBL5658306 | 0.65 | NTRK1 (1.00) | NTRK1ITKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347971-A1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | Bristol-Myers Squibb Company (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002050071-A1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |