Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.55 |
| ▸ | ITK | Q08881 | 4/20 | 0.51 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005843 | 0.86 | NTRK1 (0.56) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL7005357 | 0.80 | NTRK1 (0.66) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL5660312 | 0.75 | NTRK1 (0.75) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL7005166 | 0.74 | NTRK1 (0.64) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL5659180 | 0.71 | NTRK1 (1.00) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL5659305 | 0.70 | NTRK1 (0.70) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL14460999 | 0.68 | ITK (1.00) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL16557138 | 0.67 | NTRK1 (1.00) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL5658306 | 0.67 | NTRK1 (1.00) | NTRK1CDK2ITKMETIGF1R | |
| SCHEMBL7002646 | 0.67 | NTRK1 (0.76) | NTRK1CDK2ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347971-A1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | Bristol-Myers Squibb Company (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002050071-A1 | THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |