SCHEMBL7005992

SCHEMBL7005992

CN(C)C1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4cc(N)c(F)cc4F)c3c2Cl)C1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.58
CYP2C9 P11712 2/20 0.58
ALDH1A1 P00352 1/20 0.48
POLB P06746 1/20 0.48
CHRM2 P08172 1/20 0.48
CHRM1 P11229 1/20 0.48
OPRM1 P35372 1/20 0.48
OPRD1 P41143 1/20 0.48
TOP2A P11388 14/20 0.44
TOP1 P11387 8/20 0.44
TOP2B Q02880 7/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7008772 0.89 CYP3A4 (0.61) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7004804 0.89 CYP3A4 (0.71) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7009205 0.88 CYP3A4 (0.60) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7007374 0.88 CYP3A4 (0.58) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL8484766 0.88 CYP3A4 (0.58) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL8478761 0.87 CYP3A4 (0.59) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7012828 0.87 CYP3A4 (0.59) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7006855 0.87 CYP3A4 (0.59) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7011751 0.86 CYP3A4 (0.65) CYP3A4CYP2C9ALDH1A1POLBCHRM2
Hydrochloric Acid SCHEMBL8483495 0.85 CYP3A4 (0.57) CYP3A4CYP2C9ALDH1A1POLBCHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787720-B1 PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KK (JP) 2003-07-16 EP disclosed
US-5910498-A NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1999-06-08 US disclosed