Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.49 |
| ▸ | TEK | Q02763 | 7/20 | 0.49 |
| ▸ | LCK | P06239 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | EGFR | P00533 | 9/20 | 0.47 |
| ▸ | ABL1 | P00519 | 6/20 | 0.47 |
| ▸ | ABL2 | P42684 | 6/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 4/20 | 0.44 |
| ▸ | KIF5B | P33176 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2074968 | 0.91 | SRC (0.48) | SRCTEKLCKKDREGFR | |
| SCHEMBL7005371 | 0.90 | TEK (0.61) | SRCTEKLCKKDREGFR | |
| SCHEMBL2074527 | 0.85 | ABL1 (0.50) | SRCTEKLCKKDREGFR | |
| SCHEMBL6867277 | 0.83 | EIF2AK3 (0.47) | SRCTEKLCKKDRRIPK2 | |
| SCHEMBL7855168 | 0.83 | SRC (0.57) | SRCTEKLCKKDREGFR | |
| SCHEMBL6861029 | 0.83 | LCK (0.59) | SRCTEKLCKKDREGFR | |
| SCHEMBL6465409 | 0.80 | LCK (0.74) | SRCTEKLCKKDREGFR | |
| SCHEMBL6465401 | 0.80 | LCK (0.74) | SRCTEKLCKKDREGFR | |
| SCHEMBL7006750 | 0.80 | SRC (0.61) | SRCTEKLCKKDREGFR | |
| SCHEMBL6871561 | 0.80 | RET (0.44) | SRCTEKKDREGFRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |