Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.66 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.66 |
| ▸ | TMIGD3 | P0DMS9 | 5/20 | 0.66 |
| ▸ | CDK1 | P06493 | 9/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008061 | 0.83 | CDK1 (0.59) | ADORA2AADORA1ADORA2BTMIGD3CDK1 | |
| SCHEMBL7146120 | 0.83 | CCNB2 (0.52) | ADORA2AADORA1ADORA2BTMIGD3CDK1 | |
| SCHEMBL2310972 | 0.82 | CDK1 (0.58) | ADORA2AADORA1ADORA2BTMIGD3CDK1 | |
| SCHEMBL8677222 | 0.81 | CDK1 (0.57) | ADORA2AADORA1ADORA2BTMIGD3CDK1 | |
| SCHEMBL7008070 | 0.81 | CDK1 (0.57) | ADORA2AADORA1ADORA2BTMIGD3CDK1 | |
| SCHEMBL7008067 | 0.80 | CDK1 (0.57) | ADORA2AADORA1ADORA2BTMIGD3CDK1 | |
| SCHEMBL2098867 | 0.79 | CDK1 (0.63) | ADORA2AADORA1ADORA2BTMIGD3CDK1 | |
| SCHEMBL3877499 | 0.77 | CDK1 (0.53) | ADORA2AADORA1ADORA2BTMIGD3CDK1 | |
| SCHEMBL754120 | 0.76 | CDK1 (1.00) | ADORA2AADORA1TMIGD3CDK1CCNB2 | |
| SCHEMBL30539284 | 0.76 | CDK1 (1.00) | ADORA2AADORA1TMIGD3CDK1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030191086-A1 | Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof | USTAV EXPERIMENTALNI BOTANIKY AV CR | 2003-10-09 | — | — | US | disclosed |
| EP-1147108-B1 | SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF | USTAV EX BOTAN AKADEMIE VED CE (CZ) | 2003-08-13 | — | — | EP | disclosed |
| US-6552192-B1 | Inhibiting cyclin dependent kinase proteins, viruses, and immunostimulation; antimitotic, antiviral, anticancinogenic, antidegenerative, immunosuppressive | USTAU EXPERIMENTALNI BOTANIKY AV-CR (CZ) | 2003-04-22 | — | — | US | disclosed |
| EP-1147108-A1 | SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF | Ustav Experimentalni Botaniky Akademie ved Ceské Republiky (CZ) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000043394-A1 | SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF | ÚSTAV EXPERIMENTÁLNÍ BOTANIKY AV CR (CZ) | 2000-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191086-A1 | Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof | CDK4, CDK5, CCNI | ADORA2A 1059/4885ADORA1 2213/4885ADORA2B 2889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.