Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 6/20 | 0.38 |
| ▸ | FLT3 | P36888 | 4/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 7/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006373 | 0.91 | EGFR (0.37) | MERTKFLT3TYRO3GAS6EGFR | |
| SCHEMBL722277 | 0.82 | CHUK (0.42) | MERTKFLT3TYRO3GAS6MAPK8 | |
| SCHEMBL3250942 | 0.82 | CHUK (0.42) | MERTKFLT3TYRO3GAS6MAPK8 | |
| SCHEMBL3253565 | 0.82 | CHUK (0.42) | MERTKFLT3TYRO3GAS6MAPK8 | |
| SCHEMBL3244787 | 0.80 | TP53 (0.38) | MERTKFLT3TYRO3GAS6ADORA1 | |
| SCHEMBL3252430 | 0.80 | CHUK (0.44) | MERTKFLT3TYRO3GAS6MAPK8 | |
| SCHEMBL3252423 | 0.80 | CHUK (0.44) | MERTKFLT3TYRO3GAS6MAPK8 | |
| SCHEMBL3244784 | 0.80 | TP53 (0.38) | MERTKFLT3TYRO3GAS6ADORA1 | |
| SCHEMBL3251095 | 0.79 | AURKA (0.45) | BCL6SYKTP53POLBGAA | |
| SCHEMBL3253630 | 0.78 | PRKCQ (0.41) | MERTKFLT3TYRO3GAS6MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303495-A1 | SUBSTITUTED 5-ALKYNYL PYRIMIDINES HAVING NEUROTROPHIC ACTIVITY | Krenitsky Pharmaceuticals, Inc. (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008205-A1 | SUBSTITUTED 5-ALKYNYL PYRIMIDINES HAVING NEUROTROPHIC ACTIVITY | KRENITSKY PHARMACEUTICALS, INC. (US) | 2002-01-31 | — | — | WO | disclosed |