Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.75 |
| ▸ | PDE5A | O76074 | 16/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.68 |
| ▸ | PDE6C | P51160 | 2/20 | 0.68 |
| ▸ | PDE2A | O00408 | 1/20 | 0.68 |
| ▸ | PDE9A | O76083 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.68 |
| ▸ | PDE1A | P54750 | 1/20 | 0.68 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.68 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.67 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.67 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002595 | 0.95 | KDM4E (0.67) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7000157 | 0.93 | KDM4E (0.76) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7003778 | 0.92 | KDM4E (0.62) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7004586 | 0.92 | KDM4E (0.74) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7004779 | 0.91 | KDM4E (0.71) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7001089 | 0.91 | KDM4E (0.61) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7002705 | 0.91 | KDM4E (0.73) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7001505 | 0.91 | KDM4E (0.72) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7000746 | 0.88 | KDM4E (0.80) | KDM4EPDE5AKMT2AHDAC1HDAC6 | |
| SCHEMBL7004511 | 0.88 | KDM4E (0.68) | KDM4EPDE5AKMT2AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716298-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2014-05-06 | — | — | US | claimed |
| EP-2556820-A2 | COMPOSITION CONTAINING PDE5 INHIBITOR FOR RELIEVING SKIN WRINKLES | SK Chemicals, Co., Ltd. (KR) | 2013-02-13 | — | — | EP | claimed |
| US-20130030174-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2013-01-31 | — | — | US | claimed |
| EP-1129093-B1 | PYRAZOLOPYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF IMPOTENCE | DONG A PHARM CO LTD (KR) | 2003-07-23 | — | — | EP | claimed |
| US-6583147-B1 | 5-(2-ethoxy-5-(isopropylamidosulfonyl)phenyl)-1-methyl-3-propy l- 1,6-dihydro-7H-pyrazolo(4,3-d)pyrimidin-7-one; | DONG A PHARM CO., LTD. (KR) | 2003-06-24 | — | — | US | claimed |
| US-9155691-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2015-10-13 | — | — | US | disclosed |
| US-20140179701-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2014-06-26 | — | — | US | disclosed |
| US-8716298-B2 | Composition for reducing skin wrinkles including PDE5 inhibitor | SK CHEMICALS CO., LTD. (KR) | 2014-05-06 | — | — | US | disclosed |
| US-20130030174-A1 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR | SK CHEMICALS CO., LTD. (KR) | 2013-01-31 | — | — | US | disclosed |
| EP-1129093-B1 | PYRAZOLOPYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF IMPOTENCE | DONG A PHARM CO LTD (KR) | 2003-07-23 | — | — | EP | disclosed |
| US-6583147-B1 | 5-(2-ethoxy-5-(isopropylamidosulfonyl)phenyl)-1-methyl-3-propy l- 1,6-dihydro-7H-pyrazolo(4,3-d)pyrimidin-7-one; | DONG A PHARM CO., LTD. (KR) | 2003-06-24 | — | — | US | disclosed |