Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 5/20 | 0.65 |
| ▸ | SRC | P12931 | 11/20 | 0.60 |
| ▸ | EGFR | P00533 | 10/20 | 0.60 |
| ▸ | ABL1 | P00519 | 9/20 | 0.60 |
| ▸ | ABL2 | P42684 | 9/20 | 0.60 |
| ▸ | LCK | P06239 | 5/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.59 |
| ▸ | IGF1R | P08069 | 3/20 | 0.59 |
| ▸ | LYN | P07948 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | NPM1 | P06748 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | ROS1 | P08922 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | BCR | P11274 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12934116 | 0.92 | TEK (0.57) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL12934112 | 0.92 | SRC (0.56) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL12934118 | 0.92 | SRC (0.56) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL2074422 | 0.90 | SRC (0.67) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL12934131 | 0.90 | TEK (0.63) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL12934129 | 0.90 | TEK (0.65) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL2074647 | 0.90 | TEK (0.65) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL12934117 | 0.89 | SRC (0.66) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL7005208 | 0.89 | TEK (0.55) | TEKSRCEGFRABL1ABL2 | |
| SCHEMBL12934136 | 0.89 | TEK (0.62) | TEKSRCEGFRABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1134439-C | Pyrrolo [2,3D ] pyrimidines and their use as tyrosine kinase inhibitors | 艾博特股份有限两合公司 | 2004-01-14 | — | — | CN | claimed |
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | claimed |
| CN-1259950-A | Pyrrolo [2,3D] pyrimidines and their use as tyrosine kinase inhibitors | BASF AG (DE) | 2000-07-12 | — | — | CN | claimed |
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |