Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 11/20 | 0.70 |
| ▸ | EDNRB | P24530 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008278 | 1.00 | EDNRA (0.70) | EDNRAEDNRBKMT2AALDH1A1LMNA | |
| SCHEMBL7006902 | 1.00 | EDNRA (0.70) | EDNRAEDNRBKMT2AALDH1A1LMNA | |
| SCHEMBL7006380 | 0.95 | EDNRA (0.65) | EDNRAEDNRB | |
| SCHEMBL7013111 | 0.91 | EDNRA (0.80) | EDNRAEDNRBKMT2AMEN1 | |
| SCHEMBL7006427 | 0.90 | EDNRA (0.81) | EDNRAEDNRBKMT2AMEN1CCR9 | |
| SCHEMBL7009309 | 0.87 | EDNRA (0.76) | EDNRAEDNRBKMT2AMEN1CCR9 | |
| SCHEMBL9157048 | 0.86 | EDNRA (0.73) | EDNRAEDNRBKMT2ALMNAMEN1 | |
| SCHEMBL9152177 | 0.84 | EDNRA (0.72) | EDNRAEDNRBKMT2ALMNAMEN1 | |
| SCHEMBL7014774 | 0.84 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL7008565 | 0.84 | EDNRA (0.53) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | claimed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | claimed |
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-5420129-A | Treatment of hypertension, ischemia, vasospasms, angina | HOFFMANN-LA ROCHE INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |