Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 9/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836939 | 0.90 | PARP1 (0.62) | PARP1DHODH | |
| SCHEMBL6841484 | 0.80 | PARP1 (0.62) | PARP1DHODH | |
| SCHEMBL6842037 | 0.79 | DHODH (0.44) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL828410 | 0.79 | PARP1 (0.61) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL2789377 | 0.76 | KDM4E (0.60) | PARP1KDM4EHPGDDHODH | |
| SCHEMBL6836933 | 0.76 | PARP1 (0.60) | PARP1 | |
| SCHEMBL6841345 | 0.76 | PARP1 (0.64) | PARP1 | |
| SCHEMBL6836775 | 0.76 | PARP1 (0.64) | PARP1 | |
| SCHEMBL6841885 | 0.76 | PARP1 (0.64) | PARP1 | |
| SCHEMBL6836754 | 0.75 | PARP1 (0.65) | PARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003106430-A1 | BENZIMIDAZOLE INHIBITORS OF POLY(ADP-RIBOSYL) POLYMERASE | PFIZER INC. (US) | 2003-12-24 | — | — | WO | disclosed |