Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5640234 | 1.00 | DPP4 (0.55) | DPP4L3MBTL1ALDH1A1CYP3A4ADORA3 | |
| SCHEMBL5640697 | 0.97 | DPP4 (0.58) | DPP4L3MBTL1ALDH1A1ADORA3ADORA2A | |
| SCHEMBL7093975 | 0.95 | DPP4 (0.55) | DPP4L3MBTL1ALDH1A1 | |
| SCHEMBL14524035 | 0.92 | DPP4 (0.55) | DPP4L3MBTL1ALDH1A1ADORA3ADORA2A | |
| SCHEMBL5643390 | 0.90 | DPP4 (0.64) | DPP4L3MBTL1ALDH1A1 | |
| SCHEMBL5641006 | 0.90 | DPP4 (0.67) | DPP4L3MBTL1ALDH1A1ADORA3ADORA2A | |
| SCHEMBL5641163 | 0.90 | DPP4 (0.67) | DPP4L3MBTL1ALDH1A1 | |
| SCHEMBL5641369 | 0.88 | DPP4 (0.58) | DPP4L3MBTL1ALDH1A1ADORA3ADORA2A | |
| SCHEMBL5641325 | 0.87 | DPP4 (0.62) | DPP4L3MBTL1ALDH1A1 | |
| SCHEMBL5642076 | 0.86 | DPP4 (0.72) | DPP4L3MBTL1ALDH1A1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301187-A2 | HETEROCYCLIC COMPOUNDS, WHICH ARE INHIBITORS OF THE ENZYME DPP-IV | NOVO NORDISK A/S (DK) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002002560-A2 | PURINE-2,6-DIONES WHICH ARE INHIBITORS OF THE ENZYME DIPEPTIDYL PEPTIDASE IV (DPP-IV) | NOVO NORDISK A/S (DK) | 2002-01-10 | — | — | WO | disclosed |