Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 12/20 | 0.53 |
| ▸ | EGFR | P00533 | 11/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.44 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766845 | 0.89 | EGFR (0.55) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL7008019 | 0.84 | ERBB2 (0.57) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL8458493 | 0.84 | ERBB2 (0.57) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL7013188 | 0.83 | ERBB2 (0.53) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL4559023 | 0.83 | ERBB2 (0.72) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL7013191 | 0.82 | ERBB2 (0.52) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL7912128 | 0.80 | ERBB2 (0.53) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL7912134 | 0.79 | ERBB2 (0.52) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL7888585 | 0.79 | EGFR (0.61) | ERBB2EGFRAURKBCHEK2ROS1 | |
| SCHEMBL7008017 | 0.79 | ERBB2 (0.57) | ERBB2EGFRAURKBCHEK2ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912572-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2003-01-15 | — | — | EP | disclosed |
| US-6207669-B1 | IN TREATMENT OF CANCER AND PSORIASIS | GLAXO WELLCOME INC. | 2001-03-27 | — | — | US | disclosed |
| CN-1230185-A | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LTD (GB) | 1999-09-29 | — | — | CN | disclosed |
| EP-0912572-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998002437-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1998-01-22 | — | — | WO | disclosed |