Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | IDO1 | P14902 | 3/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FER | P16591 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006381 | 0.86 | TDP1 (0.69) | TDP1IDO1MAOAMAOBPDGFRA | |
| SCHEMBL7819483 | 0.86 | PDPK1 (0.56) | TDP1IDO1GALR3CHEK1LTK | |
| SCHEMBL7819481 | 0.86 | PDPK1 (0.56) | TDP1IDO1GALR3CHEK1LTK | |
| SCHEMBL7012831 | 0.84 | TDP1 (0.67) | TDP1IDO1MAOAMAOBPDGFRA | |
| SCHEMBL7014287 | 0.84 | TDP1 (0.71) | TDP1IDO1MAOAMAOBPDGFRA | |
| SCHEMBL5468788 | 0.81 | TDP1 (0.68) | TDP1IDO1MAOAMAOBPDGFRA | |
| SCHEMBL14448871 | 0.81 | TDP1 (0.68) | TDP1IDO1MAOAMAOBPDGFRA | |
| SCHEMBL725960 | 0.80 | TDP1 (1.00) | TDP1IDO1LRRK2TDO2ALDH1A1 | |
| SCHEMBL29670839 | 0.80 | TDP1 (1.00) | TDP1IDO1LRRK2TDO2ALDH1A1 | |
| SCHEMBL7012183 | 0.80 | TDP1 (0.66) | TDP1IDO1MAOAMAOBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0816338-B1 | 3-(BIS-SUBSTITUTED-PHENYLMETHYLENE)OXINDOLE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-5965600-A | 3-(bis-substituted phenylmethylene) oxindole derivatives | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0816338-A1 | 3-(BIS-SUBSTITUTED-PHENYLMETHYLENE)OXINDOLE DERIVATIVES | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 1998-01-07 | — | — | EP | disclosed |