Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 19/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.65 |
| ▸ | F2 | P00734 | 2/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006420 | 1.00 | F10 (0.65) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL7008870 | 0.95 | F10 (0.63) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL7006282 | 0.94 | F10 (0.62) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL6296861 | 0.94 | F10 (0.66) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL7597733 | 0.93 | F10 (0.73) | F10PRSS1PRSS2PRSS3 | |
| SCHEMBL7005930 | 0.93 | F10 (0.63) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL6297021 | 0.91 | F10 (0.65) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL6424055 | 0.91 | F10 (0.53) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL7007797 | 0.90 | F10 (0.53) | F10PRSS1F2PRSS2PRSS3 | |
| SCHEMBL6422067 | 0.90 | F10 (0.53) | F10PRSS1F2PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268413-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-01-02 | — | — | EP | claimed |
| WO-2001070678-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-09-27 | — | — | WO | claimed |
| EP-1268413-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070678-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-09-27 | — | — | WO | disclosed |