Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 9/20 | 0.61 |
| ▸ | TOP2A | P11388 | 9/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011977 | 0.86 | TOP1 (0.52) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL7006508 | 0.85 | TOP1 (0.54) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL7007269 | 0.84 | TOP1 (0.51) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL7007354 | 0.84 | PIM1 (0.56) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL7010330 | 0.83 | TOP1 (0.52) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL7005195 | 0.82 | TOP1 (0.53) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL7012382 | 0.82 | TOP1 (0.48) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL6210375 | 0.82 | TOP1 (0.53) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL7005976 | 0.81 | CYP3A4 (0.55) | TOP1TOP2APIM1ALDH1A1POLB | |
| SCHEMBL7007852 | 0.81 | TOP1 (0.52) | TOP1TOP2APIM1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945435-B1 | NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | WAKUNAGA PHARMA CO LTD (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-6136823-A | BACTERICIDES OR VIRICIDES | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0945435-A1 | NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |